Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient

Metagenomic next-generation sequencing (mNGS) is a novel approach to identify pathogens undetected by conventional methods. Herein, we report a case in which mNGS was used to identify JC virus from the cerebrospinal fluid sample of an HIV positive patient with progressive multifocal leukoencephalopa...

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Main Authors:	Huan Xia, Yuanlin Guan, Silvère D. Zaongo, Han Xia, Ziyu Wang, Zhongfang Yan, Ping Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-11-01
Series:	Frontiers in Neurology
Subjects:	progressive multifocal leukoencephalopathy metagenomic next-generation sequencing cerebrospinal fluid HIV PML
Online Access:	https://www.frontiersin.org/article/10.3389/fneur.2019.01202/full

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spelling	doaj-33ffcc7c61bc4d1b84919ddb5a351f012020-11-25T00:53:43ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-11-011010.3389/fneur.2019.01202474480Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV PatientHuan Xia0Yuanlin Guan1Silvère D. Zaongo2Han Xia3Ziyu Wang4Zhongfang Yan5Ping Ma6Department of Infectious Disease, Tianjin Second People's Hospital, Tianjin, ChinaHugobiotech Co., Ltd, Beijing, ChinaDepartment of Infectious Disease, Tianjin Second People's Hospital, Tianjin, ChinaHugobiotech Co., Ltd, Beijing, ChinaDepartment of Infectious Disease, Tianjin Second People's Hospital, Tianjin, ChinaDepartment of Infectious Disease, Tianjin Second People's Hospital, Tianjin, ChinaDepartment of Infectious Disease, Tianjin Second People's Hospital, Tianjin, ChinaMetagenomic next-generation sequencing (mNGS) is a novel approach to identify pathogens undetected by conventional methods. Herein, we report a case in which mNGS was used to identify JC virus from the cerebrospinal fluid sample of an HIV positive patient with progressive multifocal leukoencephalopathy (PML).https://www.frontiersin.org/article/10.3389/fneur.2019.01202/fullprogressive multifocal leukoencephalopathymetagenomic next-generation sequencingcerebrospinal fluidHIVPML
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Huan Xia Yuanlin Guan Silvère D. Zaongo Han Xia Ziyu Wang Zhongfang Yan Ping Ma
spellingShingle	Huan Xia Yuanlin Guan Silvère D. Zaongo Han Xia Ziyu Wang Zhongfang Yan Ping Ma Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient Frontiers in Neurology progressive multifocal leukoencephalopathy metagenomic next-generation sequencing cerebrospinal fluid HIV PML
author_facet	Huan Xia Yuanlin Guan Silvère D. Zaongo Han Xia Ziyu Wang Zhongfang Yan Ping Ma
author_sort	Huan Xia
title	Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title_short	Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title_full	Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title_fullStr	Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title_full_unstemmed	Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient
title_sort	progressive multifocal leukoencephalopathy diagnosed by metagenomic next-generation sequencing of cerebrospinal fluid in an hiv patient
publisher	Frontiers Media S.A.
series	Frontiers in Neurology
issn	1664-2295
publishDate	2019-11-01
description	Metagenomic next-generation sequencing (mNGS) is a novel approach to identify pathogens undetected by conventional methods. Herein, we report a case in which mNGS was used to identify JC virus from the cerebrospinal fluid sample of an HIV positive patient with progressive multifocal leukoencephalopathy (PML).
topic	progressive multifocal leukoencephalopathy metagenomic next-generation sequencing cerebrospinal fluid HIV PML
url	https://www.frontiersin.org/article/10.3389/fneur.2019.01202/full
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Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient

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