Heterologous Expression of Toxins from Bacterial Toxin-Antitoxin Systems in Eukaryotic Cells: Strategies and Applications

Heterologous Expression of Toxins from Bacterial Toxin-Antitoxin Systems in Eukaryotic Cells: Strategies and Applications

Toxin-antitoxin (TA) systems are found in nearly all prokaryotic genomes and usually consist of a pair of co-transcribed genes, one of which encodes a stable toxin and the other, its cognate labile antitoxin. Certain environmental and physiological cues trigger the degradation of the antitoxin, caus...

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Bibliographic Details
Main Authors: Chew Chieng Yeo, Fauziah Abu Bakar, Wai Ting Chan, Manuel Espinosa, Jennifer Ann Harikrishna
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Toxins
Subjects:
toxin-antitoxin systems
genetic manipulation
gene containment
cell ablation
high expression cell lines
gene therapy
antiviral therapy
anticancer therapy
Online Access:http://www.mdpi.com/2072-6651/8/2/49

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http://www.mdpi.com/2072-6651/8/2/49

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