Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas

Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas

Isocitrate dehydrogenase (IDH) is an oncogene, and the expression of a mutated IDH promotes cell proliferation and inhibits cell differentiation. IDH exists in three different isoforms, whose mutation can cause many solid tumors, especially gliomas in adults. No effective method for classifying glio...

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Bibliographic Details
Main Authors: XiaoYong Pan, Tao Zeng, Fei Yuan, Yu-Hang Zhang, Lei Chen, LiuCun Zhu, SiBao Wan, Tao Huang, Yu-Dong Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
isocitrate dehydrogenase
methylation
IDH-mutation
gliomas
multi-class classification
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00339/full

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