Presenilin/γ-secretase and inflammation

Presenilin/γ-secretase and inflammation

Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins. Specially relevant is the γ-secretase-dependent cleavage of the β-amyloid precursor protein (APP)...

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Bibliographic Details
Main Author:	Carlos A Saura
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2010-05-01
Series:	Frontiers in Aging Neuroscience
Subjects:	Amyloid Frontotemporal Dementia Alzheimer's disease neurodegeneration Neuroinflammation Notch
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnagi.2010.00016/full

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