Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic Basis

Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic Basis

The emergence of antibiotic resistance in pathogenic bacteria has led to renewed interest in exploring the potential of plant-derived antimicrobials (PDAs) as an alternative therapeutic strategy to combat microbial infections. Historically, plant extracts have been used as a safe, effective, and nat...

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Main Authors: Abhinav Upadhyay, Indu Upadhyaya, Anup Kollanoor-Johny, Kumar Venkitanarayanan
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/761741
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spelling doaj-33ea0c69cc884b58a46714b5a98bdd5d2020-11-24T21:32:44ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/761741761741Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic BasisAbhinav Upadhyay0Indu Upadhyaya1Anup Kollanoor-Johny2Kumar Venkitanarayanan3Department of Animal Science, University of Connecticut, 3636 Horsebarn Hill Road Extension, Unit 4040, Storrs, CT 06269, USADepartment of Animal Science, University of Connecticut, 3636 Horsebarn Hill Road Extension, Unit 4040, Storrs, CT 06269, USADepartment of Animal Science, University of Connecticut, 3636 Horsebarn Hill Road Extension, Unit 4040, Storrs, CT 06269, USADepartment of Animal Science, University of Connecticut, 3636 Horsebarn Hill Road Extension, Unit 4040, Storrs, CT 06269, USAThe emergence of antibiotic resistance in pathogenic bacteria has led to renewed interest in exploring the potential of plant-derived antimicrobials (PDAs) as an alternative therapeutic strategy to combat microbial infections. Historically, plant extracts have been used as a safe, effective, and natural remedy for ailments and diseases in traditional medicine. Extensive research in the last two decades has identified a plethora of PDAs with a wide spectrum of activity against a variety of fungal and bacterial pathogens causing infections in humans and animals. Active components of many plant extracts have been characterized and are commercially available; however, research delineating the mechanistic basis of their antimicrobial action is scanty. This review highlights the potential of various plant-derived compounds to control pathogenic bacteria, especially the diverse effects exerted by plant compounds on various virulence factors that are critical for pathogenicity inside the host. In addition, the potential effect of PDAs on gut microbiota is discussed.http://dx.doi.org/10.1155/2014/761741
collection DOAJ
language English
format Article
sources DOAJ
author Abhinav Upadhyay
Indu Upadhyaya
Anup Kollanoor-Johny
Kumar Venkitanarayanan
spellingShingle Abhinav Upadhyay
Indu Upadhyaya
Anup Kollanoor-Johny
Kumar Venkitanarayanan
Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic Basis
BioMed Research International
author_facet Abhinav Upadhyay
Indu Upadhyaya
Anup Kollanoor-Johny
Kumar Venkitanarayanan
author_sort Abhinav Upadhyay
title Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic Basis
title_short Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic Basis
title_full Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic Basis
title_fullStr Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic Basis
title_full_unstemmed Combating Pathogenic Microorganisms Using Plant-Derived Antimicrobials: A Minireview of the Mechanistic Basis
title_sort combating pathogenic microorganisms using plant-derived antimicrobials: a minireview of the mechanistic basis
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description The emergence of antibiotic resistance in pathogenic bacteria has led to renewed interest in exploring the potential of plant-derived antimicrobials (PDAs) as an alternative therapeutic strategy to combat microbial infections. Historically, plant extracts have been used as a safe, effective, and natural remedy for ailments and diseases in traditional medicine. Extensive research in the last two decades has identified a plethora of PDAs with a wide spectrum of activity against a variety of fungal and bacterial pathogens causing infections in humans and animals. Active components of many plant extracts have been characterized and are commercially available; however, research delineating the mechanistic basis of their antimicrobial action is scanty. This review highlights the potential of various plant-derived compounds to control pathogenic bacteria, especially the diverse effects exerted by plant compounds on various virulence factors that are critical for pathogenicity inside the host. In addition, the potential effect of PDAs on gut microbiota is discussed.
url http://dx.doi.org/10.1155/2014/761741
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