Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

<p>Abstract</p> <p>Background</p> <p>Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. As most Alzheimer disease cases occur well past midlife, the current...

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Bibliographic Details
Main Authors: Gordon Marcia N, Freeman Melissa J, Subbarao Sangeetha, Rosenthal Arnon, Rojiani Amyn, Wilcock Donna M, Morgan Dave
Format: Article
Language:English
Published: BMC 2004-12-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/1/1/24

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http://www.jneuroinflammation.com/content/1/1/24

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