Gastrointestinal CMV Disease and Tuberculosis in an AIDS Patient: Synergistic Interaction between Opportunistic Coinfections

• Main Authors: Miriã Boaretto Teixeira Fernandes, Pedro Afonso Nogueira Moisés Cardoso, Luiza Bassani Altoé, Izana Junqueira de Castro, Guilherme Almeida Rosa da Silva, Walter de Araújo Eyer-Silva, Marcia Lyrio Sindorf, Rodrigo Panno Basílio de Oliveira, Marcelo Costa Velho Mendes de Azevedo, Jorge Francisco da Cunha Pinto
• Format: Article
• Language: English
• Published: Hindawi Limited 2018-01-01
• Series: Case Reports in Medicine
• Online Access: http://dx.doi.org/10.1155/2018/8047892

The AIDS pandemic has made diseases such as tuberculosis, CMV disease, and other opportunistic infections more prevalent; these diseases may even be found to be associated among themselves, and the natural history of each disease may present in an unusual manner. We report the case of a 41-year-old man with HIV (CD4 of 144 cells/dL) and HCV with hematochezia due to tuberculosis in the ileocecal valve and descending colon and CMV tissue invasive disease in the esophagus and descending colon. Coinfection among tuberculosis and cytomegalovirus in the gastrointestinal tract was described only once in a patient with a recent diagnosis of HIV that affected the distal ileum and ascending colon. We will discuss the peculiarities of the case and the behavior of the immune system in the face of simultaneous opportunistic infections. This is a challenging scenario that has scarce publications and is of great clinical importance.