A Case of Oxcarbazepine-Induced Severe Hyponatremia

• Main Authors: Yıldız Değirmenci, Yeliz Yılmaz, Ceyda Hayretdağ Örs, Handan Işın Özışık Karaman
• Format: Article
• Language: English
• Published: KARE Publishing 2011-01-01
• Series: Epilepsi
• Subjects: Hyponatremia; oxcarbazepine; inappropriate antidiuretic hormone secretion.
• Online Access: http://www.journalagent.com/z4/download_fulltext.asp?pdir=epilepsi&plng=tur&un=JTES-02996

Oxcarbazepine is a keto-analogue of carbamazepine. Hyponatremia seen in the patients treated with oxcarbazepine is usually asymptomatic and rarely severe which leads to drug withdrawal. Here we presented a 51-year old female patient with epilepsy under oxcarbazepine and valproate treatment, who presented to our outpatient neurology clinic with vertigo, nausea and vomitting after the usage of her antiepileptic drugs. Routine biochemistry evluations revealed a decresed serum sodium level with increased urine sodium and osmolarity levels. Renal ultrasonography was normal. The patient was pre-diagnosed as inappropriate antidiuretic hormone secretion syndrome. Three days after the oxcarbazepine withdrawal, serum and urine sodium levels were found to be normal.