Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials.

Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials.

We explored the theorized upregulation of platelet-activating factor (PAF)- mediated biologic responses following lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibition using human platelet aggregation studies in an in vitro experiment and in 2 clinical trials.Full platelet aggregation concent...

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Bibliographic Details
Main Authors: Bonnie C Shaddinger, Yanmei Xu, James H Roger, Colin H Macphee, Malcolm Handel, Charlotte A Baidoo, Mindy Magee, John J Lepore, Dennis L Sprecher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3903475?pdf=render

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