PCAF/GCN5-Mediated Acetylation of RPA1 Promotes Nucleotide Excision Repair

PCAF/GCN5-Mediated Acetylation of RPA1 Promotes Nucleotide Excision Repair

The RPA complex can integrate multiple stress signals into diverse responses by activating distinct DNA repair pathways. However, it remains unclear how RPA1 elects to activate a specific repair pathway during different types of DNA damage. Here, we report that PCAF/GCN5-mediated K163 acetylation of...

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Bibliographic Details
Main Authors: Meimei Zhao, Rui Geng, Xiang Guo, Ruoshi Yuan, Xiao Zhou, Yanyan Zhong, Yanfei Huo, Mei Zhou, Qinjian Shen, Yinglu Li, Weiguo Zhu, Jiadong Wang
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
RPA1
XPA
PCAF
acetylation and deacetylation
UV damage
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311075

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717311075

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