Controllability analysis of protein glycosylation in CHO cells.

Controllability analysis of protein glycosylation in CHO cells.

To function as intended in vivo, a majority of biopharmaceuticals require specific glycan distributions. However, achieving a precise glycan distribution during manufacturing can be challenging because glycosylation is a non-template driven cellular process, with the potential for significant uncont...

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Bibliographic Details
Main Authors: Melissa M St Amand, Kevin Tran, Devesh Radhakrishnan, Anne S Robinson, Babatunde A Ogunnaike
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3912168?pdf=render

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