Adeno-Associated Viral Delivery of GDNF Promotes Recovery of Dopaminergic Phenotype following a Unilateral 6-Hydroxydopamine Lesion

Adeno-Associated Viral Delivery of GDNF Promotes Recovery of Dopaminergic Phenotype following a Unilateral 6-Hydroxydopamine Lesion

Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for dopamine neurons that has been proposed for use in the treatment of Parkinson's disease (PD). Previous studies using viral vectors to deliver GDNF in rodent models of PD have entailed administering the virus...

Full description

Bibliographic Details
Main Authors:	John Mcgrath, Elishia Lintz, Barry J. Hoffer, Greg A. Gerhardt, E. Matthew Quintero, Ann-Charlotte Granholm Ph.D.
Format:	Article
Language:	English
Published:	SAGE Publishing 2002-04-01
Series:	Cell Transplantation
Online Access:	https://doi.org/10.3727/096020198389988

Similar Items

Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat
by: K. Slack, et al.
Published: (2010-01-01)

Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease
by: Anna-Maija Penttinen, et al.
Published: (2018-06-01)

Neuroprotective effect of Portulaca oleracea extracts against 6-hydroxydopamine-induced lesion of dopaminergic neurons
by: WALESKA B. MARTINS, et al.
Published: (2016-01-01)

The Noradrenergic System of Aged GDNF Heterozygous Mice
by: V. Zaman, et al.
Published: (2003-04-01)

GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease
by: Xavier ed'Anglemont De Tassigny, et al.
Published: (2015-02-01)

In Vivo Extracellular Recording of Striatal Neurons in the Awake Rat Following Unilateral 6-Hydroxydopamine Lesions
by: Ming-Teh Chen, et al.
Published: (2001)

Neurturin overexpression in dopaminergic neurons induces presynaptic and postsynaptic structural changes in rats with chronic 6-hydroxydopamine lesion.
by: David Reyes-Corona, et al.
Published: (2017-01-01)

A 16-Channel Automated Rotometer System for Reliable Measurement of Turning Behavior in 6-Hydroxydopamine Lesioned and Transplanted Rats
by: John L. Hudson, et al.
Published: (1993-11-01)

Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease
by: V. Rizelio, et al.
Published: (2010-01-01)

The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system
by: Edgar R Kramer
Published: (2015-01-01)

Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression.
by: Rowan P Orme, et al.
Published: (2013-01-01)

Epothilone B Benefits Nigral Dopaminergic Neurons by Attenuating Microglia Activation in the 6-Hydroxydopamine Lesion Mouse Model of Parkinson’s Disease
by: Zhongyuan Yu, et al.
Published: (2018-09-01)

Baicalein Prevents 6-Hydroxydopamine-Induced Dopaminergic Dysfunction and Lipid Peroxidation in Mice
by: Heh-In Im, et al.
Published: (2005-01-01)

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson's Disease
by: Katrine Fabricius, et al.
Published: (2017-12-01)

Characterization of a Fibrin Glue-Gdnf Slow-Release Preparation
by: Henrich Cheng, et al.
Published: (1998-01-01)

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function.
by: Anmol Kumar, et al.
Published: (2015-12-01)

Characterization of fetal antigen 1/delta-like 1 homologue expressing cells in the rat nigrostriatal system: effects of a unilateral 6-hydroxydopamine lesion.
by: Rémy Liechti, et al.
Published: (2015-01-01)

Chondroitinase ABC reduces dopaminergic nigral cell death and striatal terminal loss in a 6-hydroxydopamine partial lesion mouse model of Parkinson’s disease
by: Edward J. R. Fletcher, et al.
Published: (2019-12-01)

Adeno-Associated Viral Vectors in Neuroscience Research
by: David L. Haggerty, et al.
Published: (2020-06-01)

Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release
by: Feng Zhang, et al.
Published: (2012-01-01)

Correction: GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function.
by: Anmol Kumar, et al.
Published: (2016-01-01)

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits
by: Soledad Marton, et al.
Published: (2019-03-01)

Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats: reversal by fluoxetine.
by: Katsuaki Suzuki, et al.
Published: (2010-02-01)

Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice
by: Heather A. Boger, et al.
Published: (2009-03-01)

Adeno-associated viral vector transduction of human mesenchymal stem cells
by: S Stender, et al.
Published: (2007-05-01)

Antioxidant Effect of Alpha-Lipoic Acid in 6-Hydroxydopamine Unilateral Intrastriatal Injected Rats
by: Pavlina Andreeva-Gateva, et al.
Published: (2020-02-01)

Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: A longitudinal in-vivo study
by: Francisco Molinet-Dronda, et al.
Published: (2015-05-01)

Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice
by: Giorgio Turconi, et al.
Published: (2020-06-01)

Interleukin-1β mediates GDNF up-regulation upon dopaminergic injury in ventral midbrain cell cultures
by: Ana Saavedra, et al.
Published: (2007-01-01)

Accurate Quantification and Characterization of Adeno-Associated Viral Vectors
by: David Dobnik, et al.
Published: (2019-07-01)

Both Intracranial and Intravenous Administration of Functionalized Carbon Nanotubes Protect Dopaminergic Neuronal Death from 6-Hydroxydopamine
by: Kim OH, et al.
Published: (2020-10-01)

Modafinil Improves Catalepsy in a Rat 6-Hydroxydopamine Model of Parkinson’s Disease; Possible Involvement of Dopaminergic Neurotransmission
by: Reza Vajdi-Hokmabad, et al.
Published: (2017-09-01)

NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease
by: Li Cheng, et al.
Published: (2018-08-01)

Protective effects of DA-9805 on dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity in the models of Parkinson’s disease
by: Hyeyoon Eo, et al.
Published: (2019-09-01)

The voiding efficiency in rat models with dopaminergic brain lesions induced through unilateral and bilateral intrastriatal injections.
by: Chellappan Praveen Rajneesh, et al.
Published: (2020-01-01)

Electroacupuncture Produces the Sustained Motor Improvement in 6-Hydroxydopamine-Lesioned Mice.
by: Yan Yu, et al.
Published: (2016-01-01)

Effects of subthalamic nucleus lesions and stimulation upon corticostriatal afferents in the 6-hydroxydopamine-lesioned rat.
by: Ruth H Walker, et al.
Published: (2012-01-01)

Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo
by: Ming-Shu Mo, et al.
Published: (2018-08-01)

Neuroprotective Effects of Erucin against 6-Hydroxydopamine-Induced Oxidative Damage in a Dopaminergic-like Neuroblastoma Cell Line
by: Giorgio Cantelli-Forti, et al.
Published: (2012-08-01)

Adipose Tissue: An Emerging Target for Adeno-associated Viral Vectors
by: Rhiannon Bates, et al.
Published: (2020-12-01)