The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway

The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway

Flemingia macrophylla (Leguminosae) is a popular traditional remedy used in Taiwan as anti-inflammatory, promoting blood circulation and antidiabetes agent. Recent study also suggested its neuroprotective activity against Alzheimer's disease. Therefore, the effects of F. macrophylla on Aβ produ...

Full description

Bibliographic Details
Main Authors:	Yun-Lian Lin, Huey-Jen Tsay, Yung-Feng Liao, Mine-Fong Wu, Chuen-Neu Wang, Young-Ji Shiao
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Evidence-Based Complementary and Alternative Medicine
Online Access:	http://dx.doi.org/10.1155/2012/795843

Similar Items

Investigating the effects of Flemingia macrophylla on APP metabolism and Amyloid clearance
by: Yung-Feng Liao, et al.
Published: (2008)

Flemingia macrophylla in goat feeding
by: Isabel das Neves Oiticica, et al.
Published: (2015-09-01)

Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid β precursor protein
by: Lorena Heredia, et al.
Published: (2004-08-01)

Estrogenic Activity of Flemingia macrophylla and Their Constituents
by: Ya-Ting Tsui, et al.
Published: (2009)

Crescimento, acúmulo de nutrientes e fixação biológica de nitrogênio de Flemingia macrophylla Growth, nutrient accumulation and biological nitrogen fixation of Flemingia macrophylla
by: Alexandre Porto Salmi, et al.
Published: (2013-02-01)

Phyto-SERM Constitutes from Flemingia macrophylla
by: Yang-Chang Wu, et al.
Published: (2013-07-01)

Crocetin attenuates inflammation and amyloid-β accumulation in APPsw transgenic mice
by: Jin Zhang, et al.
Published: (2018-10-01)

Interactions of Amyloid-β with Membrane Proteins
by: Benita Wiatrak, et al.
Published: (2021-06-01)

Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters
by: Katsumi Matsuzaki
Published: (2011-01-01)

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice
by: Jin G Sheng, et al.
Published: (2003-10-01)

β—amyloid precursor protein induced apoptosis is regulated by β—amyloid precursor protein binding protein I in N18 cell
by: Pin-Tse Li, et al.
Published: (2003)

β–amyloid precursor protein induced apoptosis is regulated by β–amyloid precursor protein binding protein I in N18 cell
by: Pin-Tse Li, et al.
Published: (2003)

Flemish and Dutch Mutations in Amyloid β Precursor Protein Have Different Effects on Amyloid β Secretion
by: Chris De Jonghe, et al.
Published: (1998-10-01)

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
by: Lin Nan, et al.
Published: (2011-06-01)

Antioxidant and Antityrosinase Activity of Flemingia macrophylla and Glycine tomentella Roots
by: Bor-Sen Wang, et al.
Published: (2012-01-01)

Flemingia macrophylla Extract Ameliorates Experimental Osteoporosis in Ovariectomized Rats
by: Hui-Ya Ho, et al.
Published: (2011-01-01)

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions
by: Xuejing Li, et al.
Published: (2013-02-01)

Amyloid-β
Published: (2023)

Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders
by: Yazan S. Batarseh, et al.
Published: (2016-03-01)

Roles of the GXXXG motif in amyloid precursor protein for its dimerization and amyloid β production
by: 東出英和, et al.
Published: (2018)

Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.
by: Nina Stemmer, et al.
Published: (2013-01-01)

Apple Procyanidins Suppress Amyloid β-Protein Aggregation
by: Toshihiko Toda, et al.
Published: (2011-01-01)

β-Amyloid precursor protein (APP) and the human diseases
by: Khue Vu Nguyen
Published: (2019-10-01)

Amyloid precursor protein modulates β-catenin degradation
by: Chen Yuzhi, et al.
Published: (2007-12-01)

Caspase inhibition attenuates accumulation of β-amyloid by reducing β-secretase production and activity in rat brains after stroke
by: Man Xiong, et al.
Published: (2008-12-01)

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein
by: Lopez-Coviella Ignacio, et al.
Published: (2005-08-01)

β-Amyloid Accumulation in Neurovascular Units Following Brain Embolism
by: Feng Han, et al.
Published: (2009-01-01)

Accumulation of amyloid-β in the cerebellar cortex of essential tremor patients
by: Eric Béliveau, et al.
Published: (2015-10-01)

Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma
by: Bueche, Celine Z., et al.
Published: (2014)

Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation
by: Nicole Groh, et al.
Published: (2017-05-01)

The human β-amyloid precursor protein: biomolecular and epigenetic aspects
by: Nguyen Khue Vu
Published: (2015-03-01)

The Effect of β-amyloid protein on DNA Methylation in Endothelial Cells
by: Wei-Chieh Chen, et al.
Published: (2007)

Regulation of the β-secretase processing of the Alzheimer's amyloid precursor protein
by: Hunt, Clare Elizabeth
Published: (2008)

Physicochemical studies on aggregation mechanism of Alzheimer's amyloid β-protein
by: Yamaguchi, Takahiro
Published: (2012)

Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila.
by: Isabelle Bourdet, et al.
Published: (2015-01-01)

The interaction of hemoglobin and β-amyloid peptide
by: Chung-HsienLiao, et al.
Published: (2011)

Stability of Plasma Amyloid-β 1–40, Amyloid-β 1–42, and Total Tau Protein over Repeated Freeze/Thaw Cycles
by: Huei-Chun Liu, et al.
Published: (2020-03-01)

Diagnostic Utility of Selected Serum Dementia Biomarkers: Amyloid β-40, Amyloid β-42, Tau Protein, and YKL-40: A Review
by: Karolina Wilczyńska, et al.
Published: (2020-10-01)

Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice
by: Alejandro R. Roda, et al.
Published: (2020-09-01)

Alzheimer's amyloid‐β and tau protein accumulation is associated with decreased expression of the LDL receptor‐associated protein in human brain tissue
by: Claire E. Shepherd, et al.
Published: (2020-07-01)