Prognostic Impact of PCK1 Protein Kinase Activity-Dependent Nuclear SREBP1 Activation in Non-Small-Cell Lung Carcinoma

Prognostic Impact of PCK1 Protein Kinase Activity-Dependent Nuclear SREBP1 Activation in Non-Small-Cell Lung Carcinoma

Metabolic enzymes can perform non-metabolic functions and play critical roles in the regulation of a variety of important cellular activities. Phosphoenolpyruvate carboxykinase 1 (PCK1), a gluconeogenesis enzyme, was recently identified as an AKT-regulated protein kinase that phosphorylates INSIG1/2...

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Bibliographic Details
Main Authors: Fei Shao, Xueli Bian, Juhong Wang, Daqian Xu, Wei Guo, Hongfei Jiang, Gaoxiang Zhao, Lei Zhu, Shuai Wang, Dongming Xing, Yibo Gao, Jie He, Zhimin Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
PCK1
INSIG1/2
SREBP1
phosphorylation
lipogenesis
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.561247/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.561247/full

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