Canonical and Noncanonical Roles of Fanconi Anemia Proteins: Implications in Cancer Predisposition

Canonical and Noncanonical Roles of Fanconi Anemia Proteins: Implications in Cancer Predisposition

Fanconi anemia (FA) is a clinically and genetically heterogeneous disorder characterized by the variable presence of congenital somatic abnormalities, bone marrow failure (BMF), and a predisposition to develop cancer. Monoallelic germline mutations in at least five genes involved in the FA pathway a...

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Bibliographic Details
Main Authors: Giacomo Milletti, Luisa Strocchio, Daria Pagliara, Katia Girardi, Roberto Carta, Angela Mastronuzzi, Franco Locatelli, Francesca Nazio
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
Fanconi anemia
DNA repair
mitochondria
cancers
inflammation
Online Access:https://www.mdpi.com/2072-6694/12/9/2684

Internet

https://www.mdpi.com/2072-6694/12/9/2684

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