Effect of dexmedetomidine before induction on the inflammatory and stress response in TURP and the secretion of pain mediators after it

• Main Authors: Jing Yang, Qing Xia
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-04-01
• Series: Journal of Hainan Medical University
• Subjects: Benign prostatic hyperplasia; Transurethral resection of prostate; Inflammatory response; Stress response; Pain mediator
• Online Access: http://www.hnykdxxb.com/PDF/201804/36.pdf

Objective: To study the effect of dexmedetomidine before induction on the inflammatory and stress response in transurethral resection of prostate (TURP) and the secretion of pain mediators after it. Methods: Patients with benign prostatic hyperplasia who underwent TURP in Mianyang Central Hospital between June 2014 and March 2017 were selected as the research subjects and randomly divided into the Dex group who accepted dexmedetomidine combined with intraspinal anesthesia and the control group who accepted intraspinal anesthesia. The contents of inflammatory response indexes, stress response indexes and pain mediators in serum of the two groups were measured before surgery as well as 1 d and 3 d after surgery. Results: Serum NF-κB, TNF-α, IL-8, HMGB1, VCAM1, Cor, ACTH, AT-II, ALD and CRP levels of both groups of patients during surgery were higher than those before surgery, and serum CGRP, BK, SP and PGE2 levels 1 d and 3 d after surgery were higher than those before surgery; serum NF-κB, TNF-α, IL-8, HMGB1, VCAM1, Cor, ACTH, AT-II, ALD and CRP levels of Dex group of patients during surgery were lower than those of control group, and serum CGRP, BK, SP and PGE2 levels 1 day and 3 days after surgery were lower than those of control group. Conclusion: The application of dexmedetomidine before induction has inhibitory effect on the activation of inflammatory and stress response in TURP and the secretion of pain mediators after TURP.