Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression

Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression

<p>Abstract</p> <p>Background</p> <p>p53 is the most studied tumor suppressor and its overexpression may or may not cause cell death depending upon the genetic background of the cells. p53 is degraded by human papillomavirus (HPV) E6 protein in cervical carcinoma. Sever...

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Bibliographic Details
Main Authors: Kumari Ratna, Vijayakumar Maleppillil V, Singh Sandeep, Upadhyay Ankur K, Ajay Amrendra K, Pandey Vimal, Boppana Ramanamurthy, Bhat Manoj K
Format: Article
Language:English
Published: BMC 2010-07-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/204

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