D-mannose suppresses macrophage IL-1β production

D-mannose suppresses macrophage IL-1β production

Mannose is present at trace levels in blood and regulates cancer growth. Here the authors show that supraphysiological levels of mannose can also regulate macrophages, limiting their production of IL-1β and increasing resistance of mice to LPS-induced endotoxemia and DSS-induced colitis.

Bibliographic Details
Main Authors: Simone Torretta, Alessandra Scagliola, Luisa Ricci, Francesco Mainini, Sabrina Di Marco, Ivan Cuccovillo, Anna Kajaste-Rudnitski, David Sumpton, Kevin M. Ryan, Simone Cardaci
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20164-6
id doaj-33a11b42ec3643e18f2c5585a702657e
record_format Article
spelling doaj-33a11b42ec3643e18f2c5585a702657e2021-01-31T13:40:27ZengNature Publishing GroupNature Communications2041-17232020-12-0111111210.1038/s41467-020-20164-6D-mannose suppresses macrophage IL-1β productionSimone Torretta0Alessandra Scagliola1Luisa Ricci2Francesco Mainini3Sabrina Di Marco4Ivan Cuccovillo5Anna Kajaste-Rudnitski6David Sumpton7Kevin M. Ryan8Simone Cardaci9Cancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific InstituteCancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific InstituteCancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific InstituteCancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific InstituteCancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific InstituteSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific InstituteSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific InstituteCRUK Beatson InstituteCRUK Beatson InstituteCancer Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific InstituteMannose is present at trace levels in blood and regulates cancer growth. Here the authors show that supraphysiological levels of mannose can also regulate macrophages, limiting their production of IL-1β and increasing resistance of mice to LPS-induced endotoxemia and DSS-induced colitis.https://doi.org/10.1038/s41467-020-20164-6
collection DOAJ
language English
format Article
sources DOAJ
author Simone Torretta
Alessandra Scagliola
Luisa Ricci
Francesco Mainini
Sabrina Di Marco
Ivan Cuccovillo
Anna Kajaste-Rudnitski
David Sumpton
Kevin M. Ryan
Simone Cardaci
spellingShingle Simone Torretta
Alessandra Scagliola
Luisa Ricci
Francesco Mainini
Sabrina Di Marco
Ivan Cuccovillo
Anna Kajaste-Rudnitski
David Sumpton
Kevin M. Ryan
Simone Cardaci
D-mannose suppresses macrophage IL-1β production
Nature Communications
author_facet Simone Torretta
Alessandra Scagliola
Luisa Ricci
Francesco Mainini
Sabrina Di Marco
Ivan Cuccovillo
Anna Kajaste-Rudnitski
David Sumpton
Kevin M. Ryan
Simone Cardaci
author_sort Simone Torretta
title D-mannose suppresses macrophage IL-1β production
title_short D-mannose suppresses macrophage IL-1β production
title_full D-mannose suppresses macrophage IL-1β production
title_fullStr D-mannose suppresses macrophage IL-1β production
title_full_unstemmed D-mannose suppresses macrophage IL-1β production
title_sort d-mannose suppresses macrophage il-1β production
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-12-01
description Mannose is present at trace levels in blood and regulates cancer growth. Here the authors show that supraphysiological levels of mannose can also regulate macrophages, limiting their production of IL-1β and increasing resistance of mice to LPS-induced endotoxemia and DSS-induced colitis.
url https://doi.org/10.1038/s41467-020-20164-6
work_keys_str_mv AT simonetorretta dmannosesuppressesmacrophageil1bproduction
AT alessandrascagliola dmannosesuppressesmacrophageil1bproduction
AT luisaricci dmannosesuppressesmacrophageil1bproduction
AT francescomainini dmannosesuppressesmacrophageil1bproduction
AT sabrinadimarco dmannosesuppressesmacrophageil1bproduction
AT ivancuccovillo dmannosesuppressesmacrophageil1bproduction
AT annakajasterudnitski dmannosesuppressesmacrophageil1bproduction
AT davidsumpton dmannosesuppressesmacrophageil1bproduction
AT kevinmryan dmannosesuppressesmacrophageil1bproduction
AT simonecardaci dmannosesuppressesmacrophageil1bproduction
_version_ 1724317058131296256

Similar Items