A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma

Summary: Noise-induced hearing loss (NIHL) results from a complex interplay of damage to the sensory cells of the inner ear, dysfunction of its lateral wall, axonal retraction of type 1C spiral ganglion neurons, and activation of the immune response. We use RiboTag and single-cell RNA sequencing to...

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Bibliographic Details
Main Authors:	Beatrice Milon, Eldad D. Shulman, Kathy S. So, Christopher R. Cederroth, Erika L. Lipford, Michal Sperber, Jonathan B. Sellon, Heela Sarlus, Gabriela Pregernig, Benjamin Shuster, Yang Song, Sunayana Mitra, Joshua Orvis, Zachary Margulies, Yoko Ogawa, Christopher Shults, Didier A. Depireux, Adam T. Palermo, Barbara Canlon, Joe Burns, Ran Elkon, Ronna Hertzano
Format:	Article
Language:	English
Published:	Elsevier 2021-09-01
Series:	Cell Reports
Subjects:	noise-induced hearing loss cochlea spiral ganglion ATF STAT3 IRF7
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124721012122

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http://www.sciencedirect.com/science/article/pii/S2211124721012122

A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma

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