Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington’s Disease

Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington’s Disease

Multiple pathomechanisms triggered by mutant Huntingtin (mHTT) underlie progressive degeneration of dopaminoceptive striatal neurons in Huntington’s disease (HD). The primary cilium is a membrane compartment that functions as a hub for various pathways that are dysregulated in HD, for example, dopam...

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Bibliographic Details
Main Authors: Rasem Mustafa, Grzegorz Kreiner, Katarzyna Kamińska, Amelia-Elise J. Wood, Joachim Kirsch, Kerry L. Tucker, Rosanna Parlato
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
primary cilium
dopamine system
Huntington’s disease
mTOR
p62
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00565/full

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