Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Noroviruses can cause gastroenteritis and there is currently no licensed vaccine or specific treatment available. Here, the authors isolate human monoclonal antibodies and characterize one antibody (NORO-320) with broad reactivity to genogroup I and II noroviruses.

Bibliographic Details
Main Authors:	Gabriela Alvarado, Wilhelm Salmen, Khalil Ettayebi, Liya Hu, Banumathi Sankaran, Mary K. Estes, B. V. Venkataram Prasad, James E. Crowe
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-24649-w

id	doaj-33925668740440828a0fc9a2f93f6e1b
record_format	Article
spelling	doaj-33925668740440828a0fc9a2f93f6e1b2021-07-18T11:42:23ZengNature Publishing GroupNature Communications2041-17232021-07-0112111310.1038/s41467-021-24649-wBroadly cross-reactive human antibodies that inhibit genogroup I and II norovirusesGabriela Alvarado0Wilhelm Salmen1Khalil Ettayebi2Liya Hu3Banumathi Sankaran4Mary K. Estes5B. V. Venkataram Prasad6James E. Crowe7Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical CenterDepartment of Molecular Virology and Microbiology, Baylor College of MedicineDepartment of Molecular Virology and Microbiology, Baylor College of MedicineThe Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of MedicineBerkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley LaboratoryDepartment of Molecular Virology and Microbiology, Baylor College of MedicineDepartment of Molecular Virology and Microbiology, Baylor College of MedicineDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical CenterNoroviruses can cause gastroenteritis and there is currently no licensed vaccine or specific treatment available. Here, the authors isolate human monoclonal antibodies and characterize one antibody (NORO-320) with broad reactivity to genogroup I and II noroviruses.https://doi.org/10.1038/s41467-021-24649-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gabriela Alvarado Wilhelm Salmen Khalil Ettayebi Liya Hu Banumathi Sankaran Mary K. Estes B. V. Venkataram Prasad James E. Crowe
spellingShingle	Gabriela Alvarado Wilhelm Salmen Khalil Ettayebi Liya Hu Banumathi Sankaran Mary K. Estes B. V. Venkataram Prasad James E. Crowe Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses Nature Communications
author_facet	Gabriela Alvarado Wilhelm Salmen Khalil Ettayebi Liya Hu Banumathi Sankaran Mary K. Estes B. V. Venkataram Prasad James E. Crowe
author_sort	Gabriela Alvarado
title	Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses
title_short	Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses
title_full	Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses
title_fullStr	Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses
title_full_unstemmed	Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses
title_sort	broadly cross-reactive human antibodies that inhibit genogroup i and ii noroviruses
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-07-01
description	Noroviruses can cause gastroenteritis and there is currently no licensed vaccine or specific treatment available. Here, the authors isolate human monoclonal antibodies and characterize one antibody (NORO-320) with broad reactivity to genogroup I and II noroviruses.
url	https://doi.org/10.1038/s41467-021-24649-w
work_keys_str_mv	AT gabrielaalvarado broadlycrossreactivehumanantibodiesthatinhibitgenogroupiandiinoroviruses AT wilhelmsalmen broadlycrossreactivehumanantibodiesthatinhibitgenogroupiandiinoroviruses AT khalilettayebi broadlycrossreactivehumanantibodiesthatinhibitgenogroupiandiinoroviruses AT liyahu broadlycrossreactivehumanantibodiesthatinhibitgenogroupiandiinoroviruses AT banumathisankaran broadlycrossreactivehumanantibodiesthatinhibitgenogroupiandiinoroviruses AT marykestes broadlycrossreactivehumanantibodiesthatinhibitgenogroupiandiinoroviruses AT bvvenkataramprasad broadlycrossreactivehumanantibodiesthatinhibitgenogroupiandiinoroviruses AT jamesecrowe broadlycrossreactivehumanantibodiesthatinhibitgenogroupiandiinoroviruses
_version_	1721295870375231488

Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Similar Items