Prevalence and characteristics of methicillin‐resistant Staphylococcus aureus colonization among healthcare professionals in a university hospital in Japan

• Main Authors: Fumi Yamasaki, Seisho Takeuchi, Yoshio Uehara, Masahide Matsushita, Kazumi Arise, Norihito Morimoto, Hiromi Seo
• Format: Article
• Language: English
• Published: Wiley 2019-09-01
• Series: Journal of General and Family Medicine
• Subjects: infection control; MRSA; multilocus sequence typing; surveillance
• Online Access: https://doi.org/10.1002/jgf2.263
• ISSN: 2189-7948

Abstract Background Asymptomatic carriers of methicillin‐resistant Staphylococcus aureus (MRSA) are important sources of nosocomial transmission. MRSA may be transmitted from hospitalized patients to healthcare professionals and vice versa. Methods The prevalence of MRSA colonization among forty‐five healthcare professionals in a Japanese hospital was determined by performing surveillance cultures to identify unrecognized carriers of MRSA. All MRSA isolates were evaluated using multilocus sequence typing (MLST) to identify the transmission routes. Results The proportion of MRSA colonization was significantly higher in healthcare professionals (11.1%) than in community residents (0.72%; P < 0.0001) or admission case (2.5%; P = 0.018). MLST analysis revealed that both the ST8 and ST764 strains were identified in residents, patients, and healthcare professionals. MRSA colonization was more frequently observed among physicians (4/13; 31%) than nurses (1/32; 3%) (P = 0.020). Conclusion Multilocus sequence typing results suggest that ST8 and ST764 are involved in the occurrence of nosocomial MRSA infections. These findings emphasize the necessity for the effective education of physicians to prevent MRSA transmissions.