Synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamides

Synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamides

In the present study, we have synthesized some novel 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl)benzenesulfonamide derivatives (3a–v) and evaluated their in vitro antimicrobial activity against the representative panel of Gram-positive bacteria [Staph...

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Main Authors: N.C. Desai, Atul H. Makwana, R.D. Senta
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Journal of Saudi Chemical Society
Subjects:
1,3,5-Triazine
Pyrimidine
Isoniazid
Benzenesulfonamide
Antimicrobial activity
MIC
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610313000951
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spelling doaj-338f0e10531f42e9980dd6ff15365c5d2020-11-24T23:13:56ZengElsevierJournal of Saudi Chemical Society1319-61032017-01-0121S1S25S3410.1016/j.jscs.2013.09.006Synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamidesN.C. Desai0Atul H. Makwana1R.D. Senta2Department of Chemistry, UGC NON-SAP & DST-FIST Sponsored Department, Mahatma Gandhi Campus, Division of Medicinal Chemistry, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364 002, IndiaXRF, St. Xavier’s College, Navrangpura, Ahmedabad 380 009, IndiaDepartment of Chemistry, UGC NON-SAP & DST-FIST Sponsored Department, Mahatma Gandhi Campus, Division of Medicinal Chemistry, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364 002, IndiaIn the present study, we have synthesized some novel 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl)benzenesulfonamide derivatives (3a–v) and evaluated their in vitro antimicrobial activity against the representative panel of Gram-positive bacteria [Staphylococcus aureus (MTCC 96), Staphylococcus pyogenes (MTCC 442)], Gram-negative bacteria [Escherichia coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688)] and fungal strains [Candida albicans (MTCC 227), Aspergillus niger (MTCC 282), Aspergillus clavatus (MTCC 1323)]. Evaluation of antimicrobial activity revealed that compounds 3g, 3h, 3t, and 3v were the most active antibacterial, while compounds 3g, and 3h were the most potent antifungal agents. The structures of synthesized compounds (3a–v) were elucidated by IR, NMR spectroscopy and elemental analysis.http://www.sciencedirect.com/science/article/pii/S13196103130009511,3,5-TriazinePyrimidineIsoniazidBenzenesulfonamideAntimicrobial activityMIC
collection DOAJ
language English
format Article
sources DOAJ
author N.C. Desai
Atul H. Makwana
R.D. Senta
spellingShingle N.C. Desai
Atul H. Makwana
R.D. Senta
Synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamides
Journal of Saudi Chemical Society
1,3,5-Triazine
Pyrimidine
Isoniazid
Benzenesulfonamide
Antimicrobial activity
MIC
author_facet N.C. Desai
Atul H. Makwana
R.D. Senta
author_sort N.C. Desai
title Synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamides
title_short Synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamides
title_full Synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamides
title_fullStr Synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamides
title_full_unstemmed Synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl) benzenesulfonamides
title_sort synthesis, characterization and antimicrobial activity of some new 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-n-(pyrimidin-2-yl) benzenesulfonamides
publisher Elsevier
series Journal of Saudi Chemical Society
issn 1319-6103
publishDate 2017-01-01
description In the present study, we have synthesized some novel 4-(4-(2-isonicotinoylhydrazinyl)-6-((aryl)amino)-1,3,5-triazin-2-ylamino)-N-(pyrimidin-2-yl)benzenesulfonamide derivatives (3a–v) and evaluated their in vitro antimicrobial activity against the representative panel of Gram-positive bacteria [Staphylococcus aureus (MTCC 96), Staphylococcus pyogenes (MTCC 442)], Gram-negative bacteria [Escherichia coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688)] and fungal strains [Candida albicans (MTCC 227), Aspergillus niger (MTCC 282), Aspergillus clavatus (MTCC 1323)]. Evaluation of antimicrobial activity revealed that compounds 3g, 3h, 3t, and 3v were the most active antibacterial, while compounds 3g, and 3h were the most potent antifungal agents. The structures of synthesized compounds (3a–v) were elucidated by IR, NMR spectroscopy and elemental analysis.
topic 1,3,5-Triazine
Pyrimidine
Isoniazid
Benzenesulfonamide
Antimicrobial activity
MIC
url http://www.sciencedirect.com/science/article/pii/S1319610313000951
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AT atulhmakwana synthesischaracterizationandantimicrobialactivityofsomenew442isonicotinoylhydrazinyl6arylamino135triazin2ylaminonpyrimidin2ylbenzenesulfonamides
AT rdsenta synthesischaracterizationandantimicrobialactivityofsomenew442isonicotinoylhydrazinyl6arylamino135triazin2ylaminonpyrimidin2ylbenzenesulfonamides
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