Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway

Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway

How the tumor microenvironment educates dendritic cells (DCs) to promote tumorigenesis remains largely unknown, and the role of tumor-derived exosomes (TEXs) in tumorigenesis is controversial. Here, we report that in addition to the activation of DCs, TEXs induce DCs to produce increased interleukin...

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Bibliographic Details
Main Authors: Yingying Shen, Danfeng Guo, Lixia Weng, Shoujie Wang, Zeyu Ma, Yunshan Yang, Pingli Wang, Jianli Wang, Zhijian Cai
Format: Article
Language:English
Published: Taylor & Francis Group 2017-12-01
Series:OncoImmunology
Subjects:
dendritic cells
exosomes
hsp72
hsp105
mmp9
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1362527

Internet

http://dx.doi.org/10.1080/2162402X.2017.1362527

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