In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing

In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing

To obtain optimal yield and productivity in bioproduction, expression of pathway genes must be appropriately coordinated. Here, the authors report repurposing of base editors for simultaneous regulation of multiple gene expression and demonstrate its application in industrially important and model m...

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Bibliographic Details
Main Authors: Yu Wang, Haijiao Cheng, Yang Liu, Ye Liu, Xiao Wen, Kun Zhang, Xiaomeng Ni, Ning Gao, Liwen Fan, Zhihui Zhang, Jiao Liu, Jiuzhou Chen, Lixian Wang, Yanmei Guo, Ping Zheng, Meng Wang, Jibin Sun, Yanhe Ma
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21003-y

Internet

https://doi.org/10.1038/s41467-021-21003-y

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