In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing
To obtain optimal yield and productivity in bioproduction, expression of pathway genes must be appropriately coordinated. Here, the authors report repurposing of base editors for simultaneous regulation of multiple gene expression and demonstrate its application in industrially important and model m...
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Bibliographic Details
| Main Authors: |
Yu Wang,
Haijiao Cheng,
Yang Liu,
Ye Liu,
Xiao Wen,
Kun Zhang,
Xiaomeng Ni,
Ning Gao,
Liwen Fan,
Zhihui Zhang,
Jiao Liu,
Jiuzhou Chen,
Lixian Wang,
Yanmei Guo,
Ping Zheng,
Meng Wang,
Jibin Sun,
Yanhe Ma |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-21003-y
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