Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity

Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity

The hypocholesterolemic activity for novel ureido fibrate analogues was found to be over 100-fold greater than for any “second-generation” fibrate in cholesterol-fed rats. A comparison of 12 related analogues revealed that the optimal configuration for a urea-bridging region located between two arom...

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Bibliographic Details
Main Authors: R L Hawke, J M Chapman, D A Winegar, J A Salisbury, R M Welch, A Brown, K W Franzmann, C Sigel
Format: Article
Language:English
Published: Elsevier 1997-06-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520372011

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