Thioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model

Thioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model

Autoreactive CD4+ T cells recognizing islet-derived antigens play a primary role in type 1 diabetes. Specific suppression of such cells therefore represents a strategic target for the cure of the disease. We have developed a methodology by which CD4+ T cells acquire apoptosis-inducing properties on...

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Bibliographic Details
Main Authors: Elin Malek Abrahimians, Luc Vander Elst, Vincent A. Carlier, Jean-Marie Saint-Remy
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
NOD mouse
cytolytic CD4+ T cells
antigen-specific
MHC class II epitopes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2016.00067/full

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