T cells in the brain may contribute to attenuation of sepsis-associated depression
Sepsis-associated encephalopathy, as well as increasing mortality, has been associated with long-lasting depressive behaviour, which is thought to be caused by infection-induced neuroinflammation in the brain. Saito et al. have recently demonstrated in a mouse model of sepsis that infiltrated regula...
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| Format: | Article |
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Nature Publishing Group
2021-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01923-7 |
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doaj-336234e2d3b2466d853bd573adbed0962021-03-21T12:28:56ZengNature Publishing GroupCommunications Biology2399-36422021-03-01411210.1038/s42003-021-01923-7T cells in the brain may contribute to attenuation of sepsis-associated depressionKarli Montague-Cardoso0Communications BiologySepsis-associated encephalopathy, as well as increasing mortality, has been associated with long-lasting depressive behaviour, which is thought to be caused by infection-induced neuroinflammation in the brain. Saito et al. have recently demonstrated in a mouse model of sepsis that infiltrated regulatory T cells in the cerebral cortex mediate the resolution of neuroinflammation and alleviate anxious/depressive behaviour. Their study paves the way for further research that investigates the role of T cells in the underlying mechanisms mediating recovery of sepsis-associated depression.https://doi.org/10.1038/s42003-021-01923-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Karli Montague-Cardoso |
| spellingShingle |
Karli Montague-Cardoso T cells in the brain may contribute to attenuation of sepsis-associated depression Communications Biology |
| author_facet |
Karli Montague-Cardoso |
| author_sort |
Karli Montague-Cardoso |
| title |
T cells in the brain may contribute to attenuation of sepsis-associated depression |
| title_short |
T cells in the brain may contribute to attenuation of sepsis-associated depression |
| title_full |
T cells in the brain may contribute to attenuation of sepsis-associated depression |
| title_fullStr |
T cells in the brain may contribute to attenuation of sepsis-associated depression |
| title_full_unstemmed |
T cells in the brain may contribute to attenuation of sepsis-associated depression |
| title_sort |
t cells in the brain may contribute to attenuation of sepsis-associated depression |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-03-01 |
| description |
Sepsis-associated encephalopathy, as well as increasing mortality, has been associated with long-lasting depressive behaviour, which is thought to be caused by infection-induced neuroinflammation in the brain. Saito et al. have recently demonstrated in a mouse model of sepsis that infiltrated regulatory T cells in the cerebral cortex mediate the resolution of neuroinflammation and alleviate anxious/depressive behaviour. Their study paves the way for further research that investigates the role of T cells in the underlying mechanisms mediating recovery of sepsis-associated depression. |
| url |
https://doi.org/10.1038/s42003-021-01923-7 |
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