A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers

A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers

Follicular helper T cells (Tfh) play an essential role in the affinity maturation of the antibody response by providing help to B cells. To determine whether this CD4+ T cell subset may contribute to the spontaneous control of HIV infection, we analyzed the phenotype and function of circulating Tfh...

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Bibliographic Details
Main Authors: M. Claireaux, M. Galperin, D. Benati, A. Nouël, M. Mukhopadhyay, J. Klingler, P. de Truchis, D. Zucman, S. Hendou, F. Boufassa, C. Moog, O. Lambotte, L. A. Chakrabarti
Format: Article
Language:English
Published: American Society for Microbiology 2018-05-01
Series:mBio
Subjects:
B lymphocytes
HIV controllers
MHC-II tetramers
T follicular helper
T lymphocytes
human immunodeficiency virus
Online Access:https://doi.org/10.1128/mBio.00317-18

Internet

https://doi.org/10.1128/mBio.00317-18

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