The miRNA-29b Is Downregulated in Placenta During Gestational Diabetes Mellitus and May Alter Placenta Development by Regulating Trophoblast Migration and Invasion Through a HIF3A-Dependent Mechanism

The miRNA-29b Is Downregulated in Placenta During Gestational Diabetes Mellitus and May Alter Placenta Development by Regulating Trophoblast Migration and Invasion Through a HIF3A-Dependent Mechanism

Gestational diabetes mellitus (GDM) is a disease that changes the function of microvascular of placenta. MicroRNA (miRNA) expression in placenta may contribute to the pathogenesis of GDM. Here, we evaluate the role and function of miR-29b in the development of GDM. This study discovered that miR-29b...

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Bibliographic Details
Main Authors: Da-Guang Sun, Shi Tian, Lu Zhang, Yi Hu, Chun-Yi Guan, Xu Ma, Hong-Fei Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Endocrinology
Subjects:
miR-29b
gestational diabetes mellitus
HIF3A
placenta
human
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00169/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00169/full

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