GENETIC FACTORS OF SEPSIS IN CHILDREN
The genetic fi ngerprint holds a major relevance in the apparition, evolution and prognosis of infections. The paper focuses on polymorphisms for one nucleotide (SNPs) of the genes which encode proteins with the main role in recognizing pathogens (Toll-like receptors: TLR2, TLR4, TLR5) or in the i...
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Amaltea Medical Publishing House
2013-12-01
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| Series: | Romanian Journal of Pediatrics |
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| Online Access: | https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2013-Nr.4/EN/RJP_2013_4_EN_Art-02.pdf |
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doaj-33432744cbb549cead87a70ce0f417d32021-09-02T13:04:47ZengAmaltea Medical Publishing HouseRomanian Journal of Pediatrics1454-03982069-61752013-12-0162433834410.37897/RJP.2013.4.2GENETIC FACTORS OF SEPSIS IN CHILDRENSorin Buzinschi0Faculty of Medicine, University of Transylvania, Clinical Hospital of Children BrasovThe genetic fi ngerprint holds a major relevance in the apparition, evolution and prognosis of infections. The paper focuses on polymorphisms for one nucleotide (SNPs) of the genes which encode proteins with the main role in recognizing pathogens (Toll-like receptors: TLR2, TLR4, TLR5) or in the infl ammatory response (TNFα, IL6, IL10) and which determine the severity and the type of the infection. The allelic confi guration constitutes an important risk element for corioamniotitis, prematurity, sepsis and death. It can also be a growth factor in resistance to common infections. Post-septic immunodepression infl uences late mortality of children who have suffered from infectious shock.https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2013-Nr.4/EN/RJP_2013_4_EN_Art-02.pdfgenetic polymorphisminfectionsdeath risk |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sorin Buzinschi |
| spellingShingle |
Sorin Buzinschi GENETIC FACTORS OF SEPSIS IN CHILDREN Romanian Journal of Pediatrics genetic polymorphism infections death risk |
| author_facet |
Sorin Buzinschi |
| author_sort |
Sorin Buzinschi |
| title |
GENETIC FACTORS OF SEPSIS IN CHILDREN |
| title_short |
GENETIC FACTORS OF SEPSIS IN CHILDREN |
| title_full |
GENETIC FACTORS OF SEPSIS IN CHILDREN |
| title_fullStr |
GENETIC FACTORS OF SEPSIS IN CHILDREN |
| title_full_unstemmed |
GENETIC FACTORS OF SEPSIS IN CHILDREN |
| title_sort |
genetic factors of sepsis in children |
| publisher |
Amaltea Medical Publishing House |
| series |
Romanian Journal of Pediatrics |
| issn |
1454-0398 2069-6175 |
| publishDate |
2013-12-01 |
| description |
The genetic fi ngerprint holds a major relevance in the apparition, evolution and prognosis of infections. The
paper focuses on polymorphisms for one nucleotide (SNPs) of the genes which encode proteins with the main
role in recognizing pathogens (Toll-like receptors: TLR2, TLR4, TLR5) or in the infl ammatory response (TNFα,
IL6, IL10) and which determine the severity and the type of the infection. The allelic confi guration constitutes an
important risk element for corioamniotitis, prematurity, sepsis and death. It can also be a growth factor in resistance to common infections. Post-septic immunodepression infl uences late mortality of children who have suffered from infectious shock. |
| topic |
genetic polymorphism infections death risk |
| url |
https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2013-Nr.4/EN/RJP_2013_4_EN_Art-02.pdf |
| work_keys_str_mv |
AT sorinbuzinschi geneticfactorsofsepsisinchildren |
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1721175234647687168 |