GENETIC FACTORS OF SEPSIS IN CHILDREN
The genetic fi ngerprint holds a major relevance in the apparition, evolution and prognosis of infections. The paper focuses on polymorphisms for one nucleotide (SNPs) of the genes which encode proteins with the main role in recognizing pathogens (Toll-like receptors: TLR2, TLR4, TLR5) or in the i...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2013-12-01
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| Series: | Romanian Journal of Pediatrics |
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| Online Access: | https://revistemedicale.amaltea.ro/Romanian_Journal_of_PEDIATRICS/Revista_Romana_de_PEDIATRIE-2013-Nr.4/EN/RJP_2013_4_EN_Art-02.pdf |
| Summary: | The genetic fi ngerprint holds a major relevance in the apparition, evolution and prognosis of infections. The
paper focuses on polymorphisms for one nucleotide (SNPs) of the genes which encode proteins with the main
role in recognizing pathogens (Toll-like receptors: TLR2, TLR4, TLR5) or in the infl ammatory response (TNFα,
IL6, IL10) and which determine the severity and the type of the infection. The allelic confi guration constitutes an
important risk element for corioamniotitis, prematurity, sepsis and death. It can also be a growth factor in resistance to common infections. Post-septic immunodepression infl uences late mortality of children who have suffered from infectious shock. |
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| ISSN: | 1454-0398 2069-6175 |