Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1.

Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1.

The mediators of the DNA damage response (DDR) are highly phosphorylated by kinases that control cell proliferation, but little is known about the role of this regulation. Here we show that cell cycle phosphorylation of the prototypical DDR mediator Saccharomyces cerevisiae Rad9 depends on cyclin-de...

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Bibliographic Details
Main Authors: Carla Manuela Abreu, Ramesh Kumar, Danielle Hamilton, Andrew William Dawdy, Kevin Creavin, Sarah Eivers, Karen Finn, Jeremy Lynn Balsbaugh, Rosemary O'Connor, Patrick A Kiely, Jeffrey Shabanowitz, Donald F Hunt, Muriel Grenon, Noel Francis Lowndes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3616908?pdf=render

Internet

http://europepmc.org/articles/PMC3616908?pdf=render

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