Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of pancreatic progenitors.

Bibliographic Details
Main Authors: Sophie Escot, David Willnow, Heike Naumann, Silvia Di Francescantonio, Francesca M. Spagnoli
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07474-6
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spelling doaj-3333c45137184a129f28864d1c262e722021-05-11T10:25:28ZengNature Publishing GroupNature Communications2041-17232018-11-019111210.1038/s41467-018-07474-6Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factorsSophie Escot0David Willnow1Heike Naumann2Silvia Di Francescantonio3Francesca M. Spagnoli4Lab. of Molecular and Cellular Basis of Embryonic Development, Max-Delbrueck Center for Molecular MedicineLab. of Molecular and Cellular Basis of Embryonic Development, Max-Delbrueck Center for Molecular MedicineLab. of Molecular and Cellular Basis of Embryonic Development, Max-Delbrueck Center for Molecular MedicineLab. of Molecular and Cellular Basis of Embryonic Development, Max-Delbrueck Center for Molecular MedicineLab. of Molecular and Cellular Basis of Embryonic Development, Max-Delbrueck Center for Molecular MedicineA role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of pancreatic progenitors.https://doi.org/10.1038/s41467-018-07474-6
collection DOAJ
language English
format Article
sources DOAJ
author Sophie Escot
David Willnow
Heike Naumann
Silvia Di Francescantonio
Francesca M. Spagnoli
spellingShingle Sophie Escot
David Willnow
Heike Naumann
Silvia Di Francescantonio
Francesca M. Spagnoli
Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
Nature Communications
author_facet Sophie Escot
David Willnow
Heike Naumann
Silvia Di Francescantonio
Francesca M. Spagnoli
author_sort Sophie Escot
title Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
title_short Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
title_full Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
title_fullStr Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
title_full_unstemmed Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors
title_sort robo signalling controls pancreatic progenitor identity by regulating tead transcription factors
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival of pancreatic progenitors.
url https://doi.org/10.1038/s41467-018-07474-6
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AT heikenaumann robosignallingcontrolspancreaticprogenitoridentitybyregulatingteadtranscriptionfactors
AT silviadifrancescantonio robosignallingcontrolspancreaticprogenitoridentitybyregulatingteadtranscriptionfactors
AT francescamspagnoli robosignallingcontrolspancreaticprogenitoridentitybyregulatingteadtranscriptionfactors
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