Ligustilide protects PC12 cells from oxygen-glucose deprivation/reoxygenation-induced apoptosis via the LKB1-AMPK-mTOR signaling pathway

Ligustilide protects PC12 cells from oxygen-glucose deprivation/reoxygenation-induced apoptosis via the LKB1-AMPK-mTOR signaling pathway

Autophagy has been shown to have a protective effect against brain damage. Ligustilide (LIG) is a bioactive substance isolated from Ligusticum chuanxiong, a traditional Chinese medicine. LIG has a neuroprotective effect; however, it is unclear whether this neuroprotective effect involves autophagy....

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Bibliographic Details
Main Authors: Dan-Yang Zhao, Dong-Dong Yu, Li Ren, Guo-Rong Bi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
AMPK; apoptosis; autophagy; Bax; Bcl-2; Beclin 1; LC3-II; ligustilide; mTOR; PC12 cells
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=473;epage=481;aulast=Zhao

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=473;epage=481;aulast=Zhao

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