Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis.

Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis.

There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs of HAT. The development of oral medications is a key objective of the Consor...

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Bibliographic Details
Main Authors: John K Thuita, Kristina K Wolf, Grace A Murilla, Qiang Liu, James N Mutuku, Yao Chen, Arlene S Bridges, Raymond E Mdachi, Mohamed A Ismail, Shelley Ching, David W Boykin, James Edwin Hall, Richard R Tidwell, Mary F Paine, Reto Brun, Michael Zhuo Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3674995?pdf=render

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