| Summary: | Adipokines are factors produced by adipose tissue, that may be proinflammatory (such as leptin and resistin) or anti-inflammatory (such as adiponectin). Effects of these adipokines on the lungs have the potential to evoke or exacerbate asthma.
Aim: Our aim was to assess if serum resistin level is changed in obese and non obese asthmatic children and if it can predict their responsiveness to inhaled glucocorticoids.
Methods: Serum levels of resistin, were measured in 60 asthmatic children (30 obese and 30 non obese asthmatic children), and in 30 age and sex matched healthy controls. The measurements were repeated in all asthmatics after 8 weeks of treatment with inhaled corticosteroids.
Results: Serum resistin levels were found to be significantly elevated in all asthmatic children than control group and it was significantly elevated in obese children, compared with asthmatic non obese and control children 35 ± 0.2 ng/mL vs 20 ± 0.25 vs 10 ± 0.11 ng/mL respectively (F < 0.005). There was negative correlation between asthma severity as detected by FEV1 and serum resistin levels. Serum resistin levels in all asthmatic children had no correlation with duration of asthma in years. Serum resistin level was significantly reduced in all asthmatic children after inhaled corticosteroids for 8 weeks. Also asthmatic children with good response to inhaled corticosteroids had high initial resistin levels compared to corticosteroids non-responder.
Conclusions: From these results we can conclude that resistin can be considered as a marker of asthma and its severity and high resistin levels can predict favourable anti-inflammatory effect of inhaled glucocorticoids suggesting that resistin may be a marker of steroid-sensitive genotype in asthma in children.
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