Vacuolar Membrane ATPase Activity 21 Predicts a Favorable Outcome and Acts as a Suppressor in Colorectal Cancer

Vacuolar Membrane ATPase Activity 21 Predicts a Favorable Outcome and Acts as a Suppressor in Colorectal Cancer

Extracellular and/or intracellular manipulation of pH in tumor may have noticeable potential in cancer treatment. Although the assembly factor genes of V0 domain of the V-ATPase complex are required for intracellular pH homeostasis, their significance in colorectal cancer (CRC) remains largely unkno...

Full description

Bibliographic Details
Main Authors:	Fan Zhang, Hao Shen, Yating Fu, Guanyu Yu, Fuao Cao, Wenjun Chang, Zhongdong Xie
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Oncology
Subjects:	vacuolar membrane ATPase activity 21 (VMA21) vacuolar ATPases prognosis tumor suppressor colorectal carcinoma
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2020.605801/full

Similar Items

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels
by: Anna L Miles, et al.
Published: (2017-03-01)

The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases
by: Qiaoyun Song, et al.
Published: (2020-05-01)

Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection
by: Hu CMJ, et al.
Published: (2018-12-01)

Defective Expression of Mitochondrial, Vacuolar H+-ATPase and Histone Genes in a C. elegans Model of SMA
by: Xiaoyang Gao, et al.
Published: (2019-05-01)

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei
by: Zhi-Shen Xu, et al.
Published: (2020-04-01)

The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells
by: Amy E. Wright, et al.
Published: (2013-09-01)

Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy
by: Summer R. Hayek, et al.
Published: (2014-01-01)

Salinity Tolerance of Two Potato Cultivars (Solanum tuberosum) Correlates With Differences in Vacuolar Transport Activity
by: Rinse Jaarsma, et al.
Published: (2018-06-01)

Cloning, Expression and Purification of Subunit H of Vacuolar H+-ATPase from Mythimna separata Walker (Lepidoptera: Noctuidae)
by: Lina Lu, et al.
Published: (2014-09-01)

Vacuolar H(+)-ATPase is not restricted to clear cells of the epididymal epithelium in cattle
by: Sung Woo Kim, et al.
Published: (2021-03-01)

Plant Proton Pumps and Cytosolic pH-Homeostasis
by: Maike Cosse, et al.
Published: (2021-06-01)

Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H+)-ATPase Inhibitors
by: Renukadevi Patil, et al.
Published: (2017-09-01)

Loss of vacuolar-type H+-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts
by: Peu Santra, et al.
Published: (2021-07-01)

The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation
by: Babatunde A. Ayodele, et al.
Published: (2017-12-01)

Augmenting Vacuolar H<sup>+</sup>-ATPase Function Prevents Cardiomyocytes from Lipid-Overload Induced Dysfunction
by: Shujin Wang, et al.
Published: (2020-02-01)

In vivo anti‐V‐ATPase antibody treatment delays ovarian tumor growth by increasing antitumor immune responses
by: Arpita Kulshrestha, et al.
Published: (2020-10-01)

V-ATPase deactivation in blowfly salivary glands is mediated by protein phosphatase 2C
by: Voss, Martin, et al.
Published: (2009)

VACUOLAR MYOPATHY
by: Marilena Alexianu, et al.
Published: (2008-06-01)

Interplay of vacuolar transporters for coupling primary and secondary active transport
by: Michèle Siek, et al.
Published: (2016-10-01)

Genome-wide survey and molecular characterization of vacuolar-ATPase subunit genes in the yellow fever mosquito Aedes aegypti (Diptera: Culicidae)
by: Coskun, Basak
Published: (2017)

The Gene Encoding Subunit A of the Vacuolar H+-ATPase From Cotton Plays an Important Role in Conferring Tolerance to Water Deficit
by: Na Liu, et al.
Published: (2018-06-01)

Vma8p-GFP Fusions Can Be Functionally Incorporated into V-ATPase, Suggesting Structural Flexibility at the Top of V1
by: Rodney J. Devenish, et al.
Published: (2011-07-01)

Characteristics of weak base-induced vacuoles formed around individual acidic organelles
by: Tadashi Kawakami, et al.
Published: (2011-07-01)

Plasma Membrane Receptors Involved in the Binding and Response of Osteoclasts to Noncellular Components of the Bone
by: Divakar S. Karanth, et al.
Published: (2021-09-01)

Differential Activity of Plasma and Vacuolar Membrane Transporters Contributes to Genotypic Differences in Salinity Tolerance in a Halophyte Species, Chenopodium quinoa
by: Edgar Bonales-Alatorre, et al.
Published: (2013-04-01)

A P3A-Type ATPase and an R2R3-MYB Transcription Factor Are Involved in Vacuolar Acidification and Flower Coloration in Soybean
by: Jagadeesh Sundaramoorthy, et al.
Published: (2020-11-01)

Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1α signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo
by: Chen M, et al.
Published: (2018-10-01)

Cancer‐associated V‐ATPase induces delayed apoptosis of protumorigenic neutrophils
by: Safaa A. Ibrahim, et al.
Published: (2020-03-01)

Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2
by: Michal Stefanik, et al.
Published: (2021-02-01)

Specialized Roles for Actin in Osteoclasts: Unanswered Questions and Therapeutic Opportunities
by: Guanghong Han, et al.
Published: (2019-01-01)

Attenuation of Candida albicans virulence with focus on disruption of its vacuole functions
by: Ingar Olsen
Published: (2014-04-01)

Proton Pump Inhibitors Modulate Transport Of Doxorubicin And Its Liposomal Form Into 2D And 3D Breast Cancer Cell Cultures
by: Paškevičiūtė M, et al.
Published: (2019-11-01)

Vacuolar Sorting Receptor-Mediated Trafficking of Soluble Vacuolar Proteins in Plant Cells
by: Hyangju Kang, et al.
Published: (2014-08-01)

Hormone-induced assembly and activation of V-ATPase in blowfly salivary glands is mediated by protein kinase A
by: Rein, Julia, et al.
Published: (2008)

A Series of Tubes: The <i>C. elegans</i> Excretory Canal Cell as a Model for Tubule Development
by: Matthew Buechner, et al.
Published: (2020-09-01)

Role of the V-ATPase a3 Subunit in Osteoclast Maturation and Function
by: Ochotny, Noelle Marie
Published: (2013)

Role of the V-ATPase a3 Subunit in Osteoclast Maturation and Function
by: Ochotny, Noelle Marie
Published: (2013)

Vacuolar iron transporter BnMEB2 is involved in enhancing iron tolerance of Brassica napus
by: Wei Zhu, et al.
Published: (2016-09-01)

PROTON PUMP INHIBITORS DISPLAY ANTITUMOR EFFECTS IN BARRETT’S ADENOCARCINOMA CELLS
by: Eduardo Chueca, et al.
Published: (2016-11-01)

F-actin reorganization by V-ATPase inhibition in prostate cancer
by: Yamhilette Licon-Munoz, et al.
Published: (2017-11-01)

Cannot write session to /tmp/vufind_sessions/sess_7evcf17aun5pscjgodm1mm9npt