Mst1-Deficiency Induces Hyperactivation of Monocyte-Derived Dendritic Cells via Akt1/c-myc Pathway

Mst1-Deficiency Induces Hyperactivation of Monocyte-Derived Dendritic Cells via Akt1/c-myc Pathway

Mst1 is a multifunctional serine/threonine kinase that is highly expressed in several immune organs. The role of Mst1 in the activation of dendritic cells (DCs), a key player of adaptive immunity, is poorly understood. In this study, we investigated the role of Mst1 in GM-CSF-induced bone marrow-der...

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Bibliographic Details
Main Authors: Kyung-Min Cho, Myun Soo Kim, Hak-Jun Jung, Eui-Ju Choi, Tae Sung Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Mst1
dendritic cells
hyperactivation
Akt1
c-myc
GM-CSF
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02142/full

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