Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing

Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing

Abstract Background Acute lymphoblastic leukemia (ALL), the most common childhood malignancy, is characterized by recurring structural chromosomal alterations and genetic alterations, whose detection is critical in diagnosis, risk stratification and prognostication. However, the genetic mechanisms t...

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Bibliographic Details
Main Authors: Honghong Zhang, Hongsheng Wang, Xiaowen Qian, Shuai Gao, Jieqi Xia, Junwen Liu, Yanqin Cheng, Jie Man, Xiaowen Zhai
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Cancer
Subjects:
Acute lymphoblastic leukemia
Genomics
Molecular pathogenesis
Pediatrics
KMT2D
Online Access:http://link.springer.com/article/10.1186/s12885-020-6709-7

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