ATP Inhibits Breast Cancer Migration and Bone Metastasis through Down-Regulation of CXCR4 and Purinergic Receptor P2Y11

ATP Inhibits Breast Cancer Migration and Bone Metastasis through Down-Regulation of CXCR4 and Purinergic Receptor P2Y11

ATP released by bone osteocytes is shown to activate purinergic signaling and inhibit the metastasis of breast cancer cells into the bone. However, the underlying molecular mechanism is not well understood. Here, we demonstrate the important roles of the CXCR4 and P2Y11 purinergic receptors in media...

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Bibliographic Details
Main Authors: Xiaowen Liu, Manuel A. Riquelme, Yi Tian, Dezhi Zhao, Francisca M. Acosta, Sumin Gu, Jean X. Jiang
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
ATP
triple-negative breast cancer
CXCR4
P2Y11
Online Access:https://www.mdpi.com/2072-6694/13/17/4293

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