Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

Indels that are commonly found in cancer genomes are characterized by non-random sequence composition and localisation. Here, the authors described a method to investigate transcriptional strand asymmetries and sequence-context specific mechanisms that alter the likelihood of insertions and deletion...

Full description

Bibliographic Details
Main Authors: Ilias Georgakopoulos-Soares, Gene Koh, Sophie E. Momen, Josef Jiricny, Martin Hemberg, Serena Nik-Zainal
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15901-w
id doaj-330a18a3bad7426cba3f743bc68365db
record_format Article
spelling doaj-330a18a3bad7426cba3f743bc68365db2021-05-11T08:37:16ZengNature Publishing GroupNature Communications2041-17232020-04-011111910.1038/s41467-020-15901-wTranscription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tractsIlias Georgakopoulos-Soares0Gene Koh1Sophie E. Momen2Josef Jiricny3Martin Hemberg4Serena Nik-Zainal5Wellcome Sanger Institute, Wellcome Genome CampusWellcome Sanger Institute, Wellcome Genome CampusAcademic Department of Medical Genetics, The Clinical School, University of CambridgeInstitute of Molecular Life Sciences, University of Zurich and Institute of Biochemistry, ETH ZurichWellcome Sanger Institute, Wellcome Genome CampusAcademic Department of Medical Genetics, The Clinical School, University of CambridgeIndels that are commonly found in cancer genomes are characterized by non-random sequence composition and localisation. Here, the authors described a method to investigate transcriptional strand asymmetries and sequence-context specific mechanisms that alter the likelihood of insertions and deletions.https://doi.org/10.1038/s41467-020-15901-w
collection DOAJ
language English
format Article
sources DOAJ
author Ilias Georgakopoulos-Soares
Gene Koh
Sophie E. Momen
Josef Jiricny
Martin Hemberg
Serena Nik-Zainal
spellingShingle Ilias Georgakopoulos-Soares
Gene Koh
Sophie E. Momen
Josef Jiricny
Martin Hemberg
Serena Nik-Zainal
Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
Nature Communications
author_facet Ilias Georgakopoulos-Soares
Gene Koh
Sophie E. Momen
Josef Jiricny
Martin Hemberg
Serena Nik-Zainal
author_sort Ilias Georgakopoulos-Soares
title Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
title_short Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
title_full Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
title_fullStr Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
title_full_unstemmed Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
title_sort transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-04-01
description Indels that are commonly found in cancer genomes are characterized by non-random sequence composition and localisation. Here, the authors described a method to investigate transcriptional strand asymmetries and sequence-context specific mechanisms that alter the likelihood of insertions and deletions.
url https://doi.org/10.1038/s41467-020-15901-w
work_keys_str_mv AT iliasgeorgakopoulossoares transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts
AT genekoh transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts
AT sophieemomen transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts
AT josefjiricny transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts
AT martinhemberg transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts
AT serenanikzainal transcriptioncoupledrepairandmismatchrepaircontributetowardspreservinggenomeintegrityatmononucleotiderepeattracts
_version_ 1721450641043226624

Similar Items