It All Depends What You Count—The Importance of Definitions in Evaluation of CF Screening Performance
Screening metrics are essential to both quality assessment and improvement, but are highly dependent on the way positive tests and cases are counted. In cystic fibrosis (CF) screening, key factors include how mild cases of late-presenting CF and CF screen positive, inconclusive diagnosis (CFSPID) ar...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | International Journal of Neonatal Screening |
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| Online Access: | https://www.mdpi.com/2409-515X/6/2/47 |
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doaj-3305514f0e0f48938a079924a2d698812020-11-25T03:07:59ZengMDPI AGInternational Journal of Neonatal Screening2409-515X2020-06-016474710.3390/ijns6020047It All Depends What You Count—The Importance of Definitions in Evaluation of CF Screening PerformanceNatasha Heather0Dianne Webster1National Newborn Metabolic Screening programme, LabPlus, Auckland City Hospital, Auckland 1148, New ZealandNational Newborn Metabolic Screening programme, LabPlus, Auckland City Hospital, Auckland 1148, New ZealandScreening metrics are essential to both quality assessment and improvement, but are highly dependent on the way positive tests and cases are counted. In cystic fibrosis (CF) screening, key factors include how mild cases of late-presenting CF and CF screen positive, inconclusive diagnosis (CFSPID) are counted, whether those at prior increased risk of CF are excluded from the screened population, and which aspects of the screening pathway are considered. This paper draws on the New Zealand experience of almost forty years of newborn screening for CF. We demonstrate how different definitions impact the calculation of screening sensitivity. We suggest that, to enable meaningful comparison, CF screening reports should clarify what steps in the screening pathway are included in the assessment, as well as the algorithm used and screening target.https://www.mdpi.com/2409-515X/6/2/47newborn screentarget disordermissed casesensitivitycystic fibrosisCFSPID |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Natasha Heather Dianne Webster |
| spellingShingle |
Natasha Heather Dianne Webster It All Depends What You Count—The Importance of Definitions in Evaluation of CF Screening Performance International Journal of Neonatal Screening newborn screen target disorder missed case sensitivity cystic fibrosis CFSPID |
| author_facet |
Natasha Heather Dianne Webster |
| author_sort |
Natasha Heather |
| title |
It All Depends What You Count—The Importance of Definitions in Evaluation of CF Screening Performance |
| title_short |
It All Depends What You Count—The Importance of Definitions in Evaluation of CF Screening Performance |
| title_full |
It All Depends What You Count—The Importance of Definitions in Evaluation of CF Screening Performance |
| title_fullStr |
It All Depends What You Count—The Importance of Definitions in Evaluation of CF Screening Performance |
| title_full_unstemmed |
It All Depends What You Count—The Importance of Definitions in Evaluation of CF Screening Performance |
| title_sort |
it all depends what you count—the importance of definitions in evaluation of cf screening performance |
| publisher |
MDPI AG |
| series |
International Journal of Neonatal Screening |
| issn |
2409-515X |
| publishDate |
2020-06-01 |
| description |
Screening metrics are essential to both quality assessment and improvement, but are highly dependent on the way positive tests and cases are counted. In cystic fibrosis (CF) screening, key factors include how mild cases of late-presenting CF and CF screen positive, inconclusive diagnosis (CFSPID) are counted, whether those at prior increased risk of CF are excluded from the screened population, and which aspects of the screening pathway are considered. This paper draws on the New Zealand experience of almost forty years of newborn screening for CF. We demonstrate how different definitions impact the calculation of screening sensitivity. We suggest that, to enable meaningful comparison, CF screening reports should clarify what steps in the screening pathway are included in the assessment, as well as the algorithm used and screening target. |
| topic |
newborn screen target disorder missed case sensitivity cystic fibrosis CFSPID |
| url |
https://www.mdpi.com/2409-515X/6/2/47 |
| work_keys_str_mv |
AT natashaheather italldependswhatyoucounttheimportanceofdefinitionsinevaluationofcfscreeningperformance AT diannewebster italldependswhatyoucounttheimportanceofdefinitionsinevaluationofcfscreeningperformance |
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