Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant

Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant

Rhabdomyolysis, a syndrome of muscle necrosis, is a life-threatening event. Here we describe the case of a patient with chronic myeloid leukemia who underwent a haploidentical stem cell transplant and subsequently developed rhabdomyolysis after beginning trimethoprim-sulfamethoxazole (TMP/SMX) proph...

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Main Authors: Alexander Augustyn, Mona Lisa Alattar, Harris Naina
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Case Reports in Oncological Medicine
Online Access:http://dx.doi.org/10.1155/2015/619473
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spelling doaj-3303590393f740f0af9687fc839b75072020-11-25T00:39:13ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/619473619473Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell TransplantAlexander Augustyn0Mona Lisa Alattar1Harris Naina2Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USASimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USASimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USARhabdomyolysis, a syndrome of muscle necrosis, is a life-threatening event. Here we describe the case of a patient with chronic myeloid leukemia who underwent a haploidentical stem cell transplant and subsequently developed rhabdomyolysis after beginning trimethoprim-sulfamethoxazole (TMP/SMX) prophylaxis therapy. Rechallenge with TMP/SMX resulted in a repeat episode of rhabdomyolysis and confirmed the association. Withdrawal of TMP/SMX led to sustained normalization of creatine kinase levels in the patient. A high index of suspicion is necessary to identify TMP/SMX as the cause of rhabdomyolysis in immunocompromised patients.http://dx.doi.org/10.1155/2015/619473
collection DOAJ
language English
format Article
sources DOAJ
author Alexander Augustyn
Mona Lisa Alattar
Harris Naina
spellingShingle Alexander Augustyn
Mona Lisa Alattar
Harris Naina
Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
Case Reports in Oncological Medicine
author_facet Alexander Augustyn
Mona Lisa Alattar
Harris Naina
author_sort Alexander Augustyn
title Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title_short Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title_full Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title_fullStr Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title_full_unstemmed Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
title_sort rhabdomyolysis due to trimethoprim-sulfamethoxazole administration following a hematopoietic stem cell transplant
publisher Hindawi Limited
series Case Reports in Oncological Medicine
issn 2090-6706
2090-6714
publishDate 2015-01-01
description Rhabdomyolysis, a syndrome of muscle necrosis, is a life-threatening event. Here we describe the case of a patient with chronic myeloid leukemia who underwent a haploidentical stem cell transplant and subsequently developed rhabdomyolysis after beginning trimethoprim-sulfamethoxazole (TMP/SMX) prophylaxis therapy. Rechallenge with TMP/SMX resulted in a repeat episode of rhabdomyolysis and confirmed the association. Withdrawal of TMP/SMX led to sustained normalization of creatine kinase levels in the patient. A high index of suspicion is necessary to identify TMP/SMX as the cause of rhabdomyolysis in immunocompromised patients.
url http://dx.doi.org/10.1155/2015/619473
work_keys_str_mv AT alexanderaugustyn rhabdomyolysisduetotrimethoprimsulfamethoxazoleadministrationfollowingahematopoieticstemcelltransplant
AT monalisaalattar rhabdomyolysisduetotrimethoprimsulfamethoxazoleadministrationfollowingahematopoieticstemcelltransplant
AT harrisnaina rhabdomyolysisduetotrimethoprimsulfamethoxazoleadministrationfollowingahematopoieticstemcelltransplant
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