A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat.

A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat.

The rat demyelination (dmy) mutation serves as a unique model system to investigate the maintenance of myelin, because it provokes severe myelin breakdown in the central nervous system (CNS) after normal postnatal completion of myelination. Here, we report the molecular characterization of this muta...

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Bibliographic Details
Main Authors: Takashi Kuramoto, Mitsuru Kuwamura, Satoko Tokuda, Takeshi Izawa, Yoshifumi Nakane, Kazuhiro Kitada, Masaharu Akao, Jean-Louis Guénet, Tadao Serikawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3017111?pdf=render

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