Screening of the matrix metalloproteinase inhibitory activity on extracts from Cordyceps neovolkiana DL0004 and Cordyceps takaomontana DL0038A fungi

• Main Authors: Nguyen Nguyet Hong, Cao Ha Tim, Nguyen Chi Dung, Dinh Minh Hiep, Ngo Ke Suong
• Format: Article
• Language: English
• Published: HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE 2020-03-01
• Series: Ho Chi Minh City Open University Journal of Science - Engineering and Technology
• Subjects: c. neovolkiana; c. takaomontana; metastasis; mmp
• Online Access: https://journalofscience.ou.edu.vn/index.php/tech-en/article/view/361

Matrix metalloproteinases (MMPs) are endopeptidases, they are involved in tumor growth, and the processes of invasion and metastasis. Cordyceps spp. were recorded to have the anticancer potential. In previous studies, extracts from Cordyceps neovolkiana strain DL0004 and Cordyceps takaomontana strain DL0038A were capable of cytotoxic activity against MCF-7 and Jurkat cell lines. In this study, 26 extracts were prepared from biomasses and fruit bodies of C. neovolkiana DL0004 and C. takaomontana DL0038A, then proceed to screen for MMP inhibition assay by concentration ranges of 2000 µg/mL, 200 µg/mL, 20 µg/mL. The results showed that the CPS extract of the fruit body of the C. neovolkiana DL0004 had the highest activity in MMP inhibition with 84.27 ± 4.59% at 2000 µg/mL. The results were achievement for further studies of metastatic inhibition activities of Cordyceps extracts.