Screening of the matrix metalloproteinase inhibitory activity on extracts from Cordyceps neovolkiana DL0004 and Cordyceps takaomontana DL0038A fungi
Matrix metalloproteinases (MMPs) are endopeptidases, they are involved in tumor growth, and the processes of invasion and metastasis. Cordyceps spp. were recorded to have the anticancer potential. In previous studies, extracts from Cordyceps neovolkiana strain DL0004 and Cordyceps takaomontana strai...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE
2020-03-01
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| Series: | Ho Chi Minh City Open University Journal of Science - Engineering and Technology |
| Subjects: | |
| Online Access: | https://journalofscience.ou.edu.vn/index.php/tech-en/article/view/361 |
| Summary: | Matrix metalloproteinases (MMPs) are endopeptidases, they are involved in tumor growth, and the processes of invasion and metastasis. Cordyceps spp. were recorded to have the anticancer potential. In previous studies, extracts from Cordyceps neovolkiana strain DL0004 and Cordyceps takaomontana strain DL0038A were capable of cytotoxic activity against MCF-7 and Jurkat cell lines. In this study, 26 extracts were prepared from biomasses and fruit bodies of C. neovolkiana DL0004 and C. takaomontana DL0038A, then proceed to screen for MMP inhibition assay by concentration ranges of 2000 µg/mL, 200 µg/mL, 20 µg/mL. The results showed that the CPS extract of the fruit body of the C. neovolkiana DL0004 had the highest activity in MMP inhibition with 84.27 ± 4.59% at 2000 µg/mL. The results were achievement for further studies of metastatic inhibition activities of Cordyceps extracts. |
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| ISSN: | 2734-9330 2734-9608 |