Analysis of the -398C/T polymorphism in the perforin gene in oncohematological patients

Analysis of the -398C/T polymorphism in the perforin gene in oncohematological patients

BACKGROUND: Recently, single nucleotide polymorphisms (SNPs) were identified in the promoter region of the perforin gene (PRF1) and it was found that the -398T mutant allele is correlated with lower amounts of protein in circulating CD8+ cytotoxic T lymphocytes. OBJECTIVE: The aim of this study was...

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Bibliographic Details
Main Authors: Fernanda Bernadelli Garcia, Rafaella Kizzy Inácio dos Reis, Lucas Emanuel Pinheiro da Silva, Helio Moraes-Souza
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Revista Brasileira de Hematologia e Hemoterapia
Subjects:
Polymorphism, genetic
Polymorphism, single nucleotide
Perforin
Hematologic neoplasms
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000400011

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000400011

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