Establishment of a doxycycline-regulated cell line with inducible, doubly-stable expression of the wild-type p53 gene from p53-deleted hepatocellular carcinoma cells

Establishment of a doxycycline-regulated cell line with inducible, doubly-stable expression of the wild-type p53 gene from p53-deleted hepatocellular carcinoma cells

<p>Abstract</p> <p>p53 is important in the development of hepatocellular carcinoma (HCC) and in therapeutic approaches, but the mechanism whereby it inhibits HCC growth is still unclear. The aim of the present study was to establish a HCC cell system in which p53 levels can be regu...

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Bibliographic Details
Main Authors: Ho Lok-Kee, Chen George G, Chi Tian-Yi, Lai Paul BS
Format: Article
Language:English
Published: BMC 2005-08-01
Series:Cancer Cell International
Subjects:
hepatocellular carcinoma
p53
tetracycline
doxycycline
gene expression.
Online Access:http://www.cancerci.com/content/5/1/27

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